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KMID : 1177320100130010042
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Korean Journal of Schizophrenia Research
2010 Volume.13 No. 1 p.42 ~ p.49
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Association Analysis between the G72/G30 Single Nucleotide Polymorphisms (rs947267 and rs77829) and Smooth Pursuit Eye Movement (SPEM) Abnormalities of Patients with Schizophrenia in Korean Population
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Lee Yeon-Jung
Lee Mi-Gyung
Kim Yoon-Jung
Han Sang-Woo
Hwang Jae-Uk
Kim Ki-Hoon
Shin Tae-Min
Park Byung-Rae
Shin Hyoung-Doo
Woo Sung-Il
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Abstract
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Objectives：We investigated the association of rs947267 and rs778294 single nucleotide polymorphisms (SNPs) on G72/G30 gene with smooth pursuit eye movement (SPEM) abnormality in Korean patients with schizophrenia.
Methods：We measured SPEM function in 216 Korean patients with schizophrenia (116 male, 100 female) and divided them into two groups (high and low), according to SPEM function. We also analyzed rs947267 and rs778294 SNPs on G72/G30 gene from the same patients. Next, we compared the differences of genotype and allele distributions of rs947267 and rs778294 SNPs on G72/G30 gene between the groups divided by the SPEM function.
Results：The natural logarithm value of signal/noise ratio (Ln S/N ratio) of the good SPEM function group was 4.39±0.33
(mean±s.d.), and that of poor SPEM function group was 3.1±0.71. There were no statistically significant differences in age or male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of rs947267 and rs778294 SNPs on G72/G30 gene between the two schizophrenia groups.
Conclusion：There were no significant differences of genotype or allele distributions of rs947267 and rs778294 SNPs on G72/ G30 gene between high and low SPEM function groups of Korean patients with schizophrenia.
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KEYWORD
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Schizophrenia, G72/G30, Smooth pursuit eye movement (SPEM), Gene, Polymorphism
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